| Product Name | CMTM8 Antibody (S-16) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | CMTM8 (CKLF-like MARVEL transmembrane domain containing 8), also known as CKLFSF8 (chemokine-like factor superfamily member 8), is a 173 amino acid member of the chemokine-like factor family. Members of the chemokine-like factor family share similarity with the chemokine and the transmembrane 4 superfamilies. CMTM8 is a multi-pass membrane protein containing one MARVEL domain. MARVEL domain-containing proteins are usually associated with specialized membrane microdomains. Through these specialized membrane microdomains, MARVEL proteins can influence a variety of cellular processes (ie., vesicular transport carriers or tight junction regulation). CMTM8 is thought to effect ligand-induced clearance of EGFR from cell membranes. This decrease in EGFR signal leads to caspase-dependent and -independent apoptosis. An alternate splice variant that does not contain the entire full-length MARVEL domain, CMTM8-v2, can still induce apoptosis without internalizing the EGFR. CMTM8 is predominantly expressed in liver and pancreas. Human CMTM8 shares 92% similarity with its mouse homolog. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of CMTM8 of human origin by WB, IF and ELISA non cross-reactive with other CMTM family members also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of CMTM8 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of CMTM8 of human origin |
| Entrez Gene | 152189 |
|---|
| Application Notes | recommended for detection of CMTM8 of human origin by WB, IF and ELISA non cross-reactive with other CMTM family members also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
