| Modification Notes |
Initiation of transcription from protein-coding genes in eukaryotes is a complex process that requires RNA polymerase II (Pol II) and several basal transcription factors to form the preinitiation complex (PIC). After initiation, promotor-specific contacts between the PIC and Pol II are disrupted, thus allowing elongation (a process regulated by Pol II and several proteins called elongation factors) to begin. TCEA2 (Transcription elongation factor A protein 2), also known as Transcription elongation factor S-II protein 2, is a 299 amino acid elongation factor that is essential for proper elongation past DNA arresting sites. When template-encoded arresting sites trap elongating RNA polymerases, the transcription complex becomes locked, preventing efficient elongation. TCEA2 binds to Pol II and functions to cleave the nascent transcript, thereby unlocking the complex and allowing transcription to continue. TCEA2 is specifically expressed in testis and ovary, suggesting possible involvement in reproductive physiology. |
