TNP1 (transition protein 1), also known as TP1 or STP1 (spermatid nuclear transition protein 1), is a 55 amino acid nuclear protein that belongs to the nuclear transition protein family. Expressed specifically in the testis, TNP1 is a spermatid-specific protein that functions as a basic chromosomal transition protein during the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in sperm nuclei. During spermatogensis, TNP1, a product of the haploid genome, replaces histone and is subsequently replaced by protamines in mature sperm. Although TNP1 is present for only a short amount of time during sperm maturation, it is thought to play an essential role in male fertility.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
recommended for detection of TNP1 of human origin by WB IP and ELISA
Tissue Specificity
recommended for detection of TNP1 of human origin by WB, IP and ELISA