Phosphatidate phosphatases are a family of integral membrane glycoproteins that dephosphorylate a variety of lipid phosphates and play a role in signal transduction via the phospholipase D pathway. PAP-2 proteins function independently of Mg2+ and are insensitive to NEM (N-ethylmaleimide) inhibition. The lipid phosphates degraded by this family include ceramide 1-phosphate (C1P), sphingosine 1-phosphate (S1P), phosphatidic acid (PA) and lysophosphatidic acid (LPA). LPPR2 (Lipid phosphate phosphatase-related protein type 2), also known as PRG4 (Plasticity-related gene 4 protein), is a 343 amino acid multi-pass membrane protein that mediates lipid phosphate phosphatase activity and may be involved in mechanisms of neuronal plasticity. There are two isoforms of LPPR2 that are produced as a result of alternative splicing events.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
recommended for detection of LPPR2 of mouse rat and human origin by WB IP and ELISA
Tissue Specificity
recommended for detection of LPPR2 of mouse, rat and human origin by WB, IP and ELISA