The transcription of ribosomal RNA genes by RNA polymerase I (Pol I) is tightly coordinated with the growth state of the cell. In addition to Pol I, transcription of ribosomal genes requires the trans-activating factor UBF (upstream binding factor). UBF functions by binding to DNA elements within the RNA gene promoter and enhancer regions and directly associating with Pol I, tethering it to the promoter complex.Related to UBF, UBTFL1 (Upstream-binding factor 1-like protein 1) is a 393 amino acid nuclear protein that contains two HMG box DNA-binding domains, which play important architectural roles in assembly of nucleoprotein complexes. The gene encoding UBTFL1 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
recommended for detection of UBTFL1 of human origin by WB IP and ELISA
Tissue Specificity
recommended for detection of UBTFL1 of human origin by WB, IP and ELISA