| Product Name | CIB2 Antibody (H-51) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | CIB2 (Calcium and integrin-binding family member 2) is a 187 amino acid protein encoded by the human gene CIB2. CIB2 is a ubiquitously expressed protein that contains three EF-hand domains. CIB2 is closely related to CIB1 (CIB1 has one less EF-hand domain), which is known to bind to Integrin aIIb in platelets and is involved in signal transduction. CIB2 expression is significantly reduced in Laminin a-2 chain deficient muscle, but is unaffected in the mouse model for Duchenne muscular dystrophy. This indicates that CIB2 is likely involved in the pathogenesis of MDC1A, a congenital muscular dystrophy caused by mutations in the gene encoding Laminin a-2 chain. CIB2 also binds to Integrin a7 and calcium, indicating that CIB2 has various functions in signalling pathways. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CIB2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 21-71 mapping within an internal region of CIB2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 21-71 mapping within an internal region of CIB2 of human origin |
| Entrez Gene | 10518 |
|---|
| Application Notes | recommended for detection of CIB2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
