Application
Western blot analysis of GRTP1 expression in non-transfected: (A) and mouse GRTP1 transfected: (B) 293T whole cell lysates.| Product Name | GRTP1 Antibody (E-17) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Pituitary growth hormone (GH), also designated somatotropin, plays a crucial role in stimulating and controlling the growth, metabolism and differentiation of many mammalian cell types by modulating the synthesis of multiple mRNA species. These effects are mediated by the binding of GH to its membrane-bound receptor, GHR, and involve a phosphorylation cascade that results in the modulation of numerous signaling pathways. GRTP1 (Growth hormone-regulated TBC protein 1), also designated TBC1 domain family member 6, is a 336 amino acid protein with expression modulated by growth hormone. The TBC1 domain of GRTP1 is a region that is notably conserved among GTPase-activating proteins, which characteristically play a role in the cell cycle and mitosis coordination. Interestingly, expression of GRTP1 is significantly upregulated in post-puberty testis and then maintained in the adult, suggesting that the germ cell may be the major site of GRTP1 function. There are two isoforms of GRTP1, which are a result of alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of GRTP1 of human, and, to a lesser extent, mouse origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of GRTP1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of GRTP1 of human origin |
| Entrez Gene | 79774 |
|---|
Application
Western blot analysis of GRTP1 expression in non-transfected: (A) and mouse GRTP1 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of GRTP1 of human, and, to a lesser extent, mouse origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
