| Product Name | ARHGAP1 Antibody (H-76) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in downregulation of their active form. ARHGAP1 (Rho GTPase activating protein 1), also known as CDC42GAP or RhoGAP1, is a 439 amino acid protein that localizes to the cytoplasm and contains one Rho-GAP domain and one CRAL-TRIO domain. Expressed ubiquitously, ARHGAP1 exists in a complex with several other proteins, including eIF4AI and Exportin 7, and functions as a GTPase activator for Rho, Rac and Cdc42 proteins, effectively converting them to an inactive GDP-bound state. The gene encoding ARHGAP1 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ARHGAP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-76 mapping at the N-terminus of ARHGAP1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-76 mapping at the N-terminus of ARHGAP1 of human origin |
| Application Notes | recommended for detection of ARHGAP1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
