| Product Name | p-hamartin Antibody (Thr 417) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder characterized by mental retardation and the widespread development of distinctive tumors termed hamartomas (1). Two different genetic loci have been linked to TSC; one of these loci, the tuberous sclerosis-2 gene (TSC2), encodes a protein called tuberin and the other loci, tuberous sclerosis-1 gene (TSC1), encodes a protein called hamartin (2,3). Tuberin and hamartin interact with each other forming a cystoplasmic complex (4,5). Hamartin interacts with the ezrin-radixin-moesin (ERM) family of actin-binding proteins and inhibition of hamartin activity results in loss of cell adhesion (6,7). Hamartin is present in most adult tissues with strong expression in brain, heart, and kidney (8). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of Thr 417 phosphorylated hamartin of human origin by WB IP and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of Thr 417 phosphorylated hamartin of human origin by WB, IP and ELISA |
| Entrez Gene | 7248 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
