| Modification Notes |
The soluble sulfotransferases contribute to the elimination of xenobiotics, the activation of procarcinogens and the regulation of hormones by catalyzing the sulfate conjugation of these substances. Members of the three groups comprising this superfamily (namely SULT1, SULT2 and SULT3) show selectivity to certain substrate compounds. SULT1 sulfotransferases exhibit N-sulfating activities of carcinogenic heterocyclic amines and are selective toward phenols, whereas SULT2 enzymes prefer hydroxysteroids and SULT3 family members are selective for N-substituted aryl and alicyclic compounds. SULT1C2 (sulfotransferase family, cytosolic, 1C, member 2), also known as ST1C1, ST1C2 or SULT1C1, is a 296 amino acid member of the SULT1 group of sulfotransferases. Localized to the cytoplasm and expressed in adult kidney, thyroid and stomach, as well as in fetal kidney and liver, SULT1C2 catalyzes the transfer of sulfate from PAPS (3'-phosphoadenosine-5'-phosphosulfate) to phenol-containing compounds, including hormones and neurotransmitters. Two isoforms of SULT1C2, designated short and long, exist as a result of alternative splicing events. |
