| Modification Notes |
Glycosyltransferases that mediate the regio- and stereoselective transfer of sugars, such as the fucosyltransferases, determine cell surface-carbohydrate profiles, which is an essential interface for biological recognition processes. Fucosyltransferases catalyze the covalent association of fucose to different positional linkages in sugar acceptor molecules. POFUT2 (Peptide-O-fucosyltransferase 2), also known as FUT13 or O-FucT-2, is a fucosyltransferase responsible for transferring fucose to serine or threonine residues in properly folded thrombospondin repeats (TSRs) through an O-glycosidic linkage. POFUT2 localizes to the endoplasmic reticulum and exists in three isoforms (designated A, B and C) which exhibit different patterns of expression. In addition, POFUT2 may have chaperone-like activity and function in quality control and protein folding. |