Application
Western blot analysis of MAFA Antibody (Center) in mouse spleen tissue lysates (35ug/lane). MAFA (arrow) was detected using the purified Pab.| Product Name | MAFA Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:50~100 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | MAFA Transcription factor MafA Pancreatic beta-cell-specific transcriptional activator Transcription factor RIPE3b1 V-maf musculoaponeurotic fibrosarcoma oncogene homolog A |
|---|---|
| Molecular Weight(MW) | 36982 Da |
| Function | Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b and activates insulin gene expression. Cooperates synergistically with NEUROD1 and PDX1 Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Involved either as an oncogene or as a tumor suppressor, depending on the cell context |
| Tissue Specificity | This MAFA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 209~238 amino acids from the Central region of human MAFA. |
| Cellular Localization | Nucleus. Note=Detected in nuclei of pancreas islet beta cells (By similarity) |
| Entrez Gene | 389692 |
|---|
Application
Western blot analysis of MAFA Antibody (Center) in mouse spleen tissue lysates (35ug/lane). MAFA (arrow) was detected using the purified Pab.| Application Notes | WB:1:50~100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
