Application
Western blot analysis of MAPK8IP2 Antibody (Center) in 293 cell line lysates (35ug/lane). MAPK8IP2 (arrow) was detected using the purified Pab.Application
MAPK8IP2 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MAPK8IP2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.Application
MAPK8IP2 Antibody (Center) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Product Name | MAPK8IP2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MAPK8IP2; IB2; JIP2; PRKM8IPL; C-Jun-amino-terminal kinase-interacting protein 2; Islet-brain-2; JNK MAP kinase scaffold protein 2; Mitogen-activated protein kinase 8-interacting protein 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHCFC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | IB2 JIP2 PRKM8IPL |
|---|---|
| Alternative Names | MAPK8IP2 IB2 JIP2 PRKM8IPL C-Jun-amino-terminal kinase-interacting protein 2 Islet-brain-2 JNK MAP kinase scaffold protein 2 Mitogen-activated protein kinase 8-interacting protein 2 |
| Molecular Weight(MW) | 87975 Da |
| Function | The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. JIP2 inhibits IL1 beta-induced apoptosis in insulin-secreting cells. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins (By similarity) |
| Tissue Specificity | Expressed mainly in the brain and pancreas, including insulin-secreting cells. In the nervous system, more abundantly expressed in the cerebellum, pituitary gland, occipital lobe and the amygdala. Also expressed in fetal brain. Very low levels found in uterus, ovary, prostate, colon, testis, adrenal gland, thyroid gland and salivary gland |
| Cellular Localization | Cytoplasm. Note=Accumulates in cell surface projections |
| Entrez Gene | 23542 |
|---|
Application
Western blot analysis of MAPK8IP2 Antibody (Center) in 293 cell line lysates (35ug/lane). MAPK8IP2 (arrow) was detected using the purified Pab.
Application
MAPK8IP2 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MAPK8IP2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Application
MAPK8IP2 Antibody (Center) flow cytometric analysis of 293 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
