Application
MAVS Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MAVS antibody detected the MAVS protein (arrow).| Product Name | MAVS Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MAVS; IPS1; KIAA1271; VISA; Mitochondrial antiviral-signaling protein; CARD adapter inducing interferon beta; Interferon beta promoter stimulator protein 1; Putative NF-kappa-B-activating protein 031N; Virus-induced-signaling adapter |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | IPS1 KIAA1271 VISA |
|---|---|
| Alternative Names | MAVS IPS1 KIAA1271 VISA Mitochondrial antiviral-signaling protein CARD adapter inducing interferon beta Interferon beta promoter stimulator protein 1 Putative NF-kappa-B-activating protein 031N Virus-induced-signaling adapter |
| Molecular Weight(MW) | 56528 Da |
| Function | Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon- independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon- dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis |
| Tissue Specificity | Present in T-cells, monocytes, epithelial cells and hepatocytes (at protein level). Ubiquitously expressed, with highest levels in heart, skeletal muscle, liver, placenta and peripheral blood leukocytes |
| Cellular Localization | Mitochondrion outer membrane. Mitochondrion. Peroxisome |
| Entrez Gene | 57506 |
|---|---|
| Nucleotide Accession | NP_065797.2 |
Application
MAVS Antibody (C-term) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the MAVS antibody detected the MAVS protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Data sheet for OM213334