Application
MBNL3 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MBNL3 antibody detected the MBNL3 protein (arrow).| Product Name | MBNL3 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MBNL3; CHCR; MBLX39; MBXL; Muscleblind-like protein 3; Cys3His CCG1-required protein; Muscleblind-like X-linked protein; Protein HCHCR |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CHCR MBLX39 MBXL |
|---|---|
| Alternative Names | MBNL3 CHCR MBLX39 MBXL Muscleblind-like protein 3 Cys3His CCG1-required protein Muscleblind-like X-linked protein Protein HCHCR |
| Molecular Weight(MW) | 38532 Da |
| Function | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction |
| Tissue Specificity | Highly expressed in the placenta. |
| Cellular Localization | Nucleus. Cytoplasm. Note=Greater concentration in the nucleus. In both DM1 and DM2 patients, colocalizes with nuclear foci of retained expanded-repeat transcripts |
| Entrez Gene | 55796 |
|---|---|
| Nucleotide Accession | NP_001164174.1 NP_001164173.1 NP_597846.1 NP_001164175.1 NP_001164172.1 NP_060858.2 |
Application
MBNL3 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MBNL3 antibody detected the MBNL3 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
