Application
MCC Antibody (Center) western blot analysis in U937 cell line lysates (35ug/lane).This demonstrates the MCC antibody detected the MCC protein (arrow).| Product Name | MCC Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MCC; Colorectal mutant cancer protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | MCC Colorectal mutant cancer protein |
|---|---|
| Molecular Weight(MW) | 93027 Da |
| Function | Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation |
| Tissue Specificity | Expressed in a variety of tissues. |
| Cellular Localization | Cell membrane. Nucleus. Cytoplasm. |
| Entrez Gene | 4163 |
|---|---|
| Nucleotide Accession | NP_002378.1 NP_001078846.1 |
Application
MCC Antibody (Center) western blot analysis in U937 cell line lysates (35ug/lane).This demonstrates the MCC antibody detected the MCC protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
