Application
MCF2L Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MCF2L antibody detected the MCF2L protein (arrow).| Product Name | MCF2L Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MCF2L; KIAA0362; Guanine nucleotide exchange factor DBS; DBL's big sister; MCF2-transforming sequence-like protein |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | KIAA0362 |
|---|---|
| Alternative Names | MCF2L KIAA0362 Guanine nucleotide exchange factor DBS DBL's big sister MCF2-transforming sequence-like protein |
| Molecular Weight(MW) | 128109 Da |
| Function | Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42 |
| Tissue Specificity | This MCF2L antibody is generated from rabbits immunized with a KLH conjugated synthetic between 1048-1075 amino acids selected from the C-terminal region of human MCF2L. |
| Cellular Localization | Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity) |
| Entrez Gene | 23263 |
|---|---|
| Nucleotide Accession | NP_001106203.1 |
Application
MCF2L Antibody (C-term) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MCF2L antibody detected the MCF2L protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
