Application
MCM6 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MCM6 antibody detected the MCM6 protein (arrow).Application
MCM6 Antibody (N-term) (AP14743a)immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MCM6 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | MCM6 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MCM6; DNA replication licensing factor MCM6; p105MCM |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | MCM6 DNA replication licensing factor MCM6 p105MCM |
|---|---|
| Molecular Weight(MW) | 92889 Da |
| Function | Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity |
| Tissue Specificity | This MCM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-109 amino acids from the N-terminal region of human MCM6. |
| Cellular Localization | Nucleus. Note=Binds to chromatin during G1 and detach from it during S phase |
| Entrez Gene | 4175 |
|---|---|
| Nucleotide Accession | NP_005906.2 |
Application
MCM6 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the MCM6 antibody detected the MCM6 protein (arrow).
Application
MCM6 Antibody (N-term) (AP14743a)immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MCM6 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
