Application
Western blot analysis of MEF2C (arrow) using rabbit polyclonal MEF2C Antibody (S387) (RB11087). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MEF2C gene (Lane 2) (Origene Technologies).Application
Formalin-fixed and paraffin-embedded human brain tissue reacted with MEF2C Antibody (S387) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Product Name | MEF2C Antibody (S387) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MEF2C; Myocyte-specific enhancer factor 2C |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | MEF2C Myocyte-specific enhancer factor 2C |
|---|---|
| Molecular Weight(MW) | 51221 Da |
| Function | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2 |
| Tissue Specificity | Expressed in brain and skeletal muscle. |
| Cellular Localization | Nucleus. |
| Entrez Gene | 4208 |
|---|
Application
Western blot analysis of MEF2C (arrow) using rabbit polyclonal MEF2C Antibody (S387) (RB11087). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the MEF2C gene (Lane 2) (Origene Technologies).
Application
Formalin-fixed and paraffin-embedded human brain tissue reacted with MEF2C Antibody (S387) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
