Application
MEX3C Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the MEX3C antibody detected the MEX3C protein (arrow).| Product Name | MEX3C Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MEX3C; RKHD2; RNF194; RNA-binding protein MEX3C; RING finger and KH domain-containing protein 2; RING finger protein 194 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | RKHD2 RNF194 |
|---|---|
| Alternative Names | MEX3C RKHD2 RNF194 RNA-binding protein MEX3C RING finger and KH domain-containing protein 2 RING finger protein 194 |
| Molecular Weight(MW) | 69366 Da |
| Function | E3 ubiquitin ligase responsible for the post- transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation |
| Tissue Specificity | Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine |
| Cellular Localization | Cytoplasm. Nucleus. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway |
| Entrez Gene | 51320 |
|---|---|
| Nucleotide Accession | NP_057710.3 |
Application
MEX3C Antibody (C-term) western blot analysis in MDA-MB453 cell line lysates (35ug/lane).This demonstrates the MEX3C antibody detected the MEX3C protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
