Application
MKRN1 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the MKRN1 antibody detected the MKRN1 protein (arrow).| Product Name | MKRN1 (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MKRN1; RNF61; E3 ubiquitin-protein ligase makorin-1; RING finger protein 61 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | RNF61 |
|---|---|
| Alternative Names | MKRN1 RNF61 E3 ubiquitin-protein ligase makorin-1 RING finger protein 61 |
| Molecular Weight(MW) | 53349 Da |
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription |
| Tissue Specificity | Ubiquitous. |
| Entrez Gene | 23608 |
|---|---|
| Nucleotide Accession | NP_038474.2 |
Application
MKRN1 Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the MKRN1 antibody detected the MKRN1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
