Application
A. Western blot analysis human spleen lysate using anti-MMP-14 RabMAb (Cat. #AJ1495a), dilution 1:2000.Application
B. Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-MMP-14 RabMAb (Cat. #AJ1495a).| Product Name | MMP-14 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MMP14, Matrix metalloproteinase-14, MMP-X1 |
| Clonality | Monoclonal |
|---|---|
| Clone Number | EP1264Y |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:5000~20000 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | MMP14 Matrix metalloproteinase-14 MMP-X1 |
|---|---|
| Molecular Weight(MW) | 65894 Da |
| Function | Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15 |
| Tissue Specificity | Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors |
| Cellular Localization | Membrane; Single-pass type I membrane protein (Potential). Melanosome. Cytoplasm. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Forms a complex with BST2 and localizes to the cytoplasm |
| Entrez Gene | 4323 |
|---|
Application
A. Western blot analysis human spleen lysate using anti-MMP-14 RabMAb (Cat. #AJ1495a), dilution 1:2000.
Application
B. Immunohistochemical staining of paraffin-embedded human breast carcinoma using anti-MMP-14 RabMAb (Cat. #AJ1495a).| Application Notes | WB:1:5000~20000 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. |
