Application
Mouse Aurkc Antibody (C-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Aurkc antibody detected the Aurkc protein (arrow).Application
Mouse Aurkc Antibody (C-term) (AP14704b)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Aurkc Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | Aurkc Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Aurkc; Aie1; Aik3; Airk3; Ark3; Stk13; Aurora kinase C; Aurora 3; Aurora/IPL1-related kinase 3; Aurora/IPL1/Eg2 protein 1; Serine/threonine-protein kinase 13; Serine/threonine-protein kinase aurora-C |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Aie1 Aik3 Airk3 Ark3 Stk13 |
|---|---|
| Alternative Names | Aurkc Aie1 Aik3 Airk3 Ark3 Stk13 Aurora kinase C Aurora 3 Aurora/IPL1-related kinase 3 Aurora/IPL1/Eg2 protein 1 Serine/threonine-protein kinase 13 Serine/threonine-protein kinase aurora-C |
| Molecular Weight(MW) | 32907 Da |
| Function | Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28' Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228' |
| Tissue Specificity | Expressed only in testis. |
| Cellular Localization | Nucleus (By similarity). Chromosome (By similarity). Chromosome, centromere (By similarity). Cytoplasm, cytoskeleton, spindle (By similarity). Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis (By similarity) |
Application
Mouse Aurkc Antibody (C-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Aurkc antibody detected the Aurkc protein (arrow).
Application
Mouse Aurkc Antibody (C-term) (AP14704b)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Aurkc Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
