Application
Mouse Camk2b Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Camk2b antibody detected the Camk2b protein (arrow).| Product Name | Camk2b Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Camk2b; Camk2d; Calcium/calmodulin-dependent protein kinase type II subunit beta |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Camk2d |
|---|---|
| Alternative Names | Camk2b Camk2d Calcium/calmodulin-dependent protein kinase type II subunit beta |
| Molecular Weight(MW) | 60461 Da |
| Function | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2 |
| Tissue Specificity | This Mouse Camk2b antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 167-196 amino acids from the Central region of Mouse Camk2b. |
| Cellular Localization | Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity) |
| Entrez Gene | 12323 |
|---|---|
| Nucleotide Accession | NP_031621.3 |
Application
Mouse Camk2b Antibody (Center) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Camk2b antibody detected the Camk2b protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
