Application
Mouse Cbx5 Antibody (C-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Cbx5 antibody detected the Cbx5 protein (arrow).| Product Name | Cbx5 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Cbx5; Hp1a; Chromobox protein homolog 5; Heterochromatin protein 1 homolog alpha |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Hp1a |
|---|---|
| Alternative Names | Cbx5 Hp1a Chromobox protein homolog 5 Heterochromatin protein 1 homolog alpha |
| Molecular Weight(MW) | 22186 Da |
| Function | Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (By similarity) |
| Tissue Specificity | This Mouse Cbx5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-186 amino acids from the C-terminal region of mouse Cbx5. |
| Cellular Localization | Nucleus. Chromosome. Chromosome, centromere. Note=Component of centromeric and pericentromeric heterochromatin Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase |
| Entrez Gene | 12419 |
|---|---|
| Nucleotide Accession | NP_001070257.1 |
Application
Mouse Cbx5 Antibody (C-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Cbx5 antibody detected the Cbx5 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
