Application
Mouse Cdc42bpb Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Cdc42bpb antibody detected the Cdc42bpb protein (arrow).| Product Name | Cdc42bpb Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Cdc42bpb; Kiaa1124; Serine/threonine-protein kinase MRCK beta; CDC42-binding protein kinase beta; DMPK-like beta; Myotonic dystrophy kinase-related CDC42-binding kinase beta |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Kiaa1124 |
|---|---|
| Alternative Names | Cdc42bpb Kiaa1124 Serine/threonine-protein kinase MRCK beta CDC42-binding protein kinase beta DMPK-like beta Myotonic dystrophy kinase-related CDC42-binding kinase beta |
| Molecular Weight(MW) | 194753 Da |
| Function | Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates PPP1R12A (By similarity) |
| Tissue Specificity | This Mouse Cdc42bpb antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 738-766 amino acids from the Central region of Mouse Cdc42bpb. |
| Cellular Localization | Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity) Cell junction (By similarity). Note=Displays a dispersed punctate distribution and concentrates along the cell periphery, especially at the leading edge and cell-cell junction. This concentration is PH-domain dependent (By similarity). Detected at the leading edge of migrating and wounded cells; this localization requires the presence of catalytically active CDC42 (By similarity) |
| Entrez Gene | 217866 |
|---|
Application
Mouse Cdc42bpb Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Cdc42bpb antibody detected the Cdc42bpb protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
