Application
Mouse Ddr2 Antibody (C-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the Ddr2 antibody detected the Ddr2 protein (arrow).Application
Mouse Ddr2 Antibody (C-term) (AP14616b)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Ddr2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | Ddr2 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Ddr2; Ntrkr3; Tkt; Tyro10; Discoidin domain-containing receptor 2; CD167 antigen-like family member B; Neurotrophic tyrosine kinase, receptor-related 3; Receptor protein-tyrosine kinase TKT; Tyrosine-protein kinase TYRO10; CD_antigen=CD167b; Flags: Precur |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Ntrkr3 Tkt Tyro10 |
|---|---|
| Alternative Names | Ddr2 Ntrkr3 Tkt Tyro10 Discoidin domain-containing receptor 2 CD167 antigen-like family member B Neurotrophic tyrosine kinase receptor-related 3 Receptor protein-tyrosine kinase TKT Tyrosine-protein kinase TYRO10 CD_antigen=CD167b Flags: Precur |
| Molecular Weight(MW) | 96482 Da |
| Function | Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing |
| Tissue Specificity | Widely expressed. Detected in lung, ovary, skin and in testis Leydig cells (at protein level). Widely expressed. Detected at high levels in heart, lung, skeletal muscle, central nervous system (CNS) and kidney, and at lower levels in brain and testis. Detected in chondrocytes in tibia growth plates of young mice |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein |
| Entrez Gene | 18214 |
|---|---|
| Nucleotide Accession | NP_072075.2 |
Application
Mouse Ddr2 Antibody (C-term) western blot analysis in mouse bladder tissue lysates (35ug/lane).This demonstrates the Ddr2 antibody detected the Ddr2 protein (arrow).
Application
Mouse Ddr2 Antibody (C-term) (AP14616b)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Ddr2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
