Application
Mouse Dmpk Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Dmpk antibody detected the Dmpk protein (arrow).| Product Name | Dmpk Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Dmpk; Dm15; Mdpk; Myotonin-protein kinase; DM-kinase; DMPK; Myotonic dystrophy protein kinase |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Dm15 Mdpk |
|---|---|
| Alternative Names | Dmpk Dm15 Mdpk Myotonin-protein kinase DM-kinase DMPK Myotonic dystrophy protein kinase |
| Molecular Weight(MW) | 69602 Da |
| Function | Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity |
| Tissue Specificity | Expressed in all tissues tested, with a predominance in brain, skeletal muscle, heart, and other tissues containing smooth muscle. In the heart, expression is restricted to the cardiomyocytes in the ventricle and atrium |
| Cellular Localization | Sarcoplasmic reticulum membrane. Cell membrane. Note=Localizes to sarcoplasmic reticulum membranes of cardiomyocytes Isoform 8: Mitochondrion outer membrane; Single-pass type IV membrane protein |
| Entrez Gene | 13400 |
|---|---|
| Nucleotide Accession | NP_001177420.1 NP_115794.1 |
Application
Mouse Dmpk Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Dmpk antibody detected the Dmpk protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
