Application
Mouse Epha1 Antibody (Center) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Epha1 antibody detected the Epha1 protein (arrow).| Product Name | Epha1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Epha1; Esk; Ephrin type-A receptor 1; Embryonic stem cell kinase; Tyrosine-protein kinase receptor ESK |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Esk |
|---|---|
| Alternative Names | Epha1 Esk Ephrin type-A receptor 1 Embryonic stem cell kinase Tyrosine-protein kinase receptor ESK |
| Molecular Weight(MW) | 108578 Da |
| Function | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis |
| Tissue Specificity | Preferentially expressed in epithelial cells including skin, kidney, liver and thymus |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein (By similarity) |
| Entrez Gene | 13835 |
|---|---|
| Nucleotide Accession | NP_076069.2 |
Application
Mouse Epha1 Antibody (Center) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Epha1 antibody detected the Epha1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
