Application
Mouse Epha2 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Epha2 antibody detected the Epha2 protein (arrow).| Product Name | Epha2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Epha2; Eck; Myk2; Sek2; Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor MPK-5; Tyrosine-protein kinase receptor SEK-2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Eck Myk2 Sek2 |
|---|---|
| Alternative Names | Epha2 Eck Myk2 Sek2 Ephrin type-A receptor 2 Epithelial cell kinase Tyrosine-protein kinase receptor ECK Tyrosine-protein kinase receptor MPK-5 Tyrosine-protein kinase receptor SEK-2 |
| Molecular Weight(MW) | 108852 Da |
| Function | Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 signaling pathway. May also participate in UV radiation- induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis |
| Tissue Specificity | Expressed in the lung, intestine and liver. |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein (By similarity). Cell projection, ruffle membrane; Single- pass type I membrane protein (By similarity). Cell projection, lamellipodium membrane; Single-pass type I membrane protein (By similarity). Cell junction, focal adhesion (By similarity) Note=Present at regions of cell-cell contacts but also at the leading edge of migrating cells (By similarity) |
| Entrez Gene | 13836 |
|---|---|
| Nucleotide Accession | NP_034269.2 |
Application
Mouse Epha2 Antibody (Center) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Epha2 antibody detected the Epha2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
