Application
Mouse Ephb4 Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Ephb4 antibody detected the Ephb4 protein (arrow).Application
Western blot analysis of Ephb4 (arrow) using rabbit polyclonal Mouse Ephb4 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Ephb4 gene.| Product Name | Ephb4 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Ephb4; Htk; Mdk2; Myk1; Ephrin type-B receptor 4; Developmental kinase 2; Hepatoma transmembrane kinase; Tyrosine kinase MYK-1 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Htk Mdk2 Myk1 |
|---|---|
| Alternative Names | Ephb4 Htk Mdk2 Myk1 Ephrin type-B receptor 4 Developmental kinase 2 Hepatoma transmembrane kinase Tyrosine kinase MYK-1 |
| Molecular Weight(MW) | 108848 Da |
| Function | Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4- mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis |
| Tissue Specificity | Expressed in various organ systems, including lung, liver, kidney, intestine, muscle and heart |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein (By similarity) |
| Entrez Gene | 13846 |
|---|
Application
Mouse Ephb4 Antibody (Center) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Ephb4 antibody detected the Ephb4 protein (arrow).
Application
Western blot analysis of Ephb4 (arrow) using rabbit polyclonal Mouse Ephb4 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the Ephb4 gene.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
