Application
Mouse Epha7 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Epha7 antibody detected the Epha7 protein (arrow).| Product Name | Epha7 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Epha7; Ebk; Ehk3; Mdk1; Ephrin type-A receptor 7; Developmental kinase 1; EPH homology kinase 3; Embryonic brain kinase |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Ebk Ehk3 Mdk1 |
|---|---|
| Alternative Names | Epha7 Ebk Ehk3 Mdk1 Ephrin type-A receptor 7 Developmental kinase 1 EPH homology kinase 3 Embryonic brain kinase |
| Molecular Weight(MW) | 111860 Da |
| Function | Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4 which lacks the kinase domain may regulate isoform 1 adhesive properties |
| Tissue Specificity | Widely expressed in embryo. In adult, expression restricted to hippocampus, testis and spleen |
| Cellular Localization | Cell membrane (Probable); Single-pass type I membrane protein (Probable) |
| Entrez Gene | 13841 |
|---|
Application
Mouse Epha7 Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Epha7 antibody detected the Epha7 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
