Application
Mouse Epha8 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the Epha8 antibody detected the Epha8 protein (arrow).| Product Name | Epha8 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Epha8; Eek; Ephrin type-A receptor 8; EPH- and ELK-related kinase; Tyrosine-protein kinase receptor EEK |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Eek |
|---|---|
| Alternative Names | Epha8 Eek Ephrin type-A receptor 8 EPH- and ELK-related kinase Tyrosine-protein kinase receptor EEK |
| Molecular Weight(MW) | 110705 Da |
| Function | Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth |
| Tissue Specificity | Specifically expressed in the central nervous system |
| Cellular Localization | Cell membrane; Single-pass type I membrane protein. Cell projection. Early endosome membrane. Note=Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes |
| Entrez Gene | 13842 |
|---|---|
| Nucleotide Accession | NP_031965.2 |
Application
Mouse Epha8 Antibody (C-term) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the Epha8 antibody detected the Epha8 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
