Application
Mouse Fap Antibody (N-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the Mouse Fap antibody detected the Mouse Fap protein (arrow).| Product Name | Fap (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Fap; Seprase; Fibroblast activation protein alpha; Integral membrane serine protease |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | Fap Seprase Fibroblast activation protein alpha Integral membrane serine protease |
|---|---|
| Molecular Weight(MW) | 87945 Da |
| Function | In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM (By similarity). May have a role in tissue remodeling during development and wound healing, and contribute to invasiveness in malignant cancers |
| Tissue Specificity | Detected in fibroblasts, in placenta, uterus, embryos from day 7-19 and in newborn mice (P1) |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein (By similarity). Cell projection, lamellipodium membrane; Single-pass type II membrane protein (By similarity). Cell projection, invadopodium membrane; Single-pass type II membrane protein (By similarity). Note=Found in cell surface lamellipodia, invadopodia and on shed vesicles. Colocalized with DPP4 in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma (By similarity) |
| Entrez Gene | 14089 |
|---|---|
| Nucleotide Accession | NP_032012.1 |
Application
Mouse Fap Antibody (N-term) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the Mouse Fap antibody detected the Mouse Fap protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
