Application
Mouse Hipk3 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the Hipk3 antibody detected the Hipk3 protein (arrow).Application
Mouse Hipk3 Antibody (C-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Hipk3 antibody detected the Hipk3 protein (arrow).| Product Name | Hipk3 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Hipk3; Fist3; Homeodomain-interacting protein kinase 3; Androgen receptor-interacting nuclear protein kinase; Fas-interacting serine/threonine-protein kinase; Nuclear body-associated kinase 3 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Fist3 |
|---|---|
| Alternative Names | Hipk3 Fist3 Homeodomain-interacting protein kinase 3 Androgen receptor-interacting nuclear protein kinase Fas-interacting serine/threonine-protein kinase Nuclear body-associated kinase 3 |
| Molecular Weight(MW) | 130081 Da |
| Function | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF- responsive element (OCFRE) |
| Tissue Specificity | Heart, skeletal muscle, spleen, testis and lung |
| Cellular Localization | Cytoplasm. Nucleus. |
| Entrez Gene | 15259 |
|---|
Application
Mouse Hipk3 Antibody (C-term) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the Hipk3 antibody detected the Hipk3 protein (arrow).
Application
Mouse Hipk3 Antibody (C-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Hipk3 antibody detected the Hipk3 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
