Application
Mouse Mark1 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Mark1 antibody detected the Mark1 protein (arrow).Application
Mouse Mark1 Antibody (C-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Mark1 antibody detected the Mark1 protein (arrow).| Product Name | Mark1 Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Mark1; Emk3; Kiaa1477; Serine/threonine-protein kinase MARK1; ELKL motif serine/threonine-protein kinase 3; MAP/microtubule affinity-regulating kinase 1; PAR1 homolog c |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Emk3 Kiaa1477 |
|---|---|
| Alternative Names | Mark1 Emk3 Kiaa1477 Serine/threonine-protein kinase MARK1 ELKL motif serine/threonine-protein kinase 3 MAP/microtubule affinity-regulating kinase 1 PAR1 homolog c |
| Molecular Weight(MW) | 88335 Da |
| Function | Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (By similarity) |
| Tissue Specificity | This Mouse Mark1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 599-627 amino acids from the C-terminal region of Mouse Mark1. |
| Cellular Localization | Cell membrane; Peripheral membrane protein (By similarity). Cytoplasm, cytoskeleton (By similarity) Note=Appears to localize to an intracellular network (By similarity) |
| Entrez Gene | 226778 |
|---|---|
| Nucleotide Accession | NP_663490.2 |
Application
Mouse Mark1 Antibody (C-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Mark1 antibody detected the Mark1 protein (arrow).
Application
Mouse Mark1 Antibody (C-term) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the Mark1 antibody detected the Mark1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
