Application
Mouse Mknk2 Antibody (N-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Mknk2 antibody detected the Mknk2 protein (arrow).| Product Name | Mknk2 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Mknk2; Mnk2; MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase signal-integrating kinase 2 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Mnk2 |
|---|---|
| Alternative Names | Mknk2 Mnk2 MAP kinase-interacting serine/threonine-protein kinase 2 MAP kinase signal-integrating kinase 2 |
| Molecular Weight(MW) | 51633 Da |
| Function | Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Enhances the formation of EIF4F complex in pachytene spermatocytes, thus promoting mRNA translation during spermatogenesis. Displays a high basal kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal |
| Tissue Specificity | Ubiquitously expressed in all tissues examined, with high levels in skeletal muscle and low levels in brain |
| Cellular Localization | Cytoplasm (By similarity). Nucleus, PML body (By similarity) |
| Entrez Gene | 17347 |
|---|---|
| Nucleotide Accession | NP_067437.1 |
Application
Mouse Mknk2 Antibody (N-term) western blot analysis in mouse lung tissue lysates (35ug/lane).This demonstrates the Mknk2 antibody detected the Mknk2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
