Application
Mouse Mst1r Antibody (C-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Mst1r antibody detected the Mst1r protein (arrow).Application
Mouse Mst1r Antibody (C-term) (AP14137b)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse live tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Mst1r Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Product Name | Mst1r Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Mst1r; Ron; Stk; Macrophage-stimulating protein receptor; Stem cell-derived tyrosine kinase; p185-Ron; CD_antigen=CD136; Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB:1:100~500 IHC |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Ron Stk |
|---|---|
| Alternative Names | Mst1r Ron Stk Macrophage-stimulating protein receptor Stem cell-derived tyrosine kinase p185-Ron CD_antigen=CD136 Macrophage-stimulating protein receptor alpha chain Macrophage-stimulating protein receptor beta chain |
| Molecular Weight(MW) | 150519 Da |
| Function | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1 Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand |
| Tissue Specificity | Expressed in liver, skin, lung, brain, testis and kidney |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Entrez Gene | 19882 |
|---|
Application
Mouse Mst1r Antibody (C-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Mst1r antibody detected the Mst1r protein (arrow).
Application
Mouse Mst1r Antibody (C-term) (AP14137b)immunohistochemistry analysis in formalin fixed and paraffin embedded mouse live tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Mouse Mst1r Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.| Application Notes | WB:1:100~500 IHC |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
