Application
Mouse Nlrp6 Antibody western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Nlrp6 antibody detected the Nlrp6 protein (arrow).| Product Name | Nlrp6 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Nlrp6; Nalp6; Pypaf5; NACHT, LRR and PYD domains-containing protein 6; Angiotensin II/vasopressin receptor; PYRIN-containing APAF1-like protein 5-like |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Nalp6 Pypaf5 |
|---|---|
| Alternative Names | Nlrp6 Nalp6 Pypaf5 NACHT LRR and PYD domains-containing protein 6 Angiotensin II/vasopressin receptor PYRIN-containing APAF1-like protein 5-like |
| Molecular Weight(MW) | 97402 Da |
| Function | May contribute to arginine-vasopressin (AVP)-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. Isoform 1 binds arginine-vasopressin but not angiotensin II and acts as an arginine-vasopressin V2 receptor. Isoform 2 binds both arginine- vasopressin and angiotensin II and acts as an angiotensin II/vasopressin receptor. Plays a role in modulating inflammatory responses in the colon to allow recovery from intestinal epithelial damage and limit tumorigenic potential. Protects against the development of colitis by controlling the composition of the gut microbiota by preventing colonization of the colon by harmful, inflammation-inducing bacteria such as Prevotella species. May mediate activation of CASP1 via ASC, promote activation of NF-kappa-B and stimulate cAMP accumulation |
| Tissue Specificity | Highly expressed in the small and large intestine, kidney and liver |
| Cellular Localization | Isoform 1: Cytoplasm (By similarity). Cell membrane (By similarity). Nucleus membrane (By similarity) |
Application
Mouse Nlrp6 Antibody western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Nlrp6 antibody detected the Nlrp6 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
