Application
Western blot analysis of anti-mFADD Pab in mouse heart tissue lysate.mFADD(arrow) was detected using the purified Pab.| Product Name | Phospho-FADD-S191 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification | p-S191 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Mort1 |
|---|---|
| Alternative Names | Fadd Mort1 Protein FADD FAS-associated death domain protein FAS-associating death domain-containing protein Mediator of receptor induced toxicity |
| Molecular Weight(MW) | 22960 Da |
| Function | Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (By similarity). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (By similarity) |
| Tissue Specificity | This Mouse Phospho-FADD-S191 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S191 of mouse FADD. |
| Entrez Gene | 14082 |
|---|
Application
Western blot analysis of anti-mFADD Pab in mouse heart tissue lysate.mFADD(arrow) was detected using the purified Pab.| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is first purified by protein G affinity chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
