Application
Mouse Pim3 Antibody (N-term) western blot analysis in human uterine tumer tissue lysates (35ug/lane).This demonstrates the Pim3 antibody detected the Pim3 protein (arrow).Application
Mouse Pim3 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Pim3 antibody detected the Pim3 protein (arrow).| Product Name | Pim3 Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | Pim3 Serine/threonine-protein kinase pim-3 |
|---|---|
| Molecular Weight(MW) | 35970 Da |
| Function | Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis and promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression and protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6 Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth |
| Tissue Specificity | Detected in pancreas but exclusively in beta- cells |
| Cellular Localization | Cytoplasm (By similarity). |
| Entrez Gene | 223775 |
|---|---|
| Nucleotide Accession | NP_663453.1 |
Application
Mouse Pim3 Antibody (N-term) western blot analysis in human uterine tumer tissue lysates (35ug/lane).This demonstrates the Pim3 antibody detected the Pim3 protein (arrow).
Application
Mouse Pim3 Antibody (N-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Pim3 antibody detected the Pim3 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
