Application
Mouse Rab17 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Mouse Rab17 antibody detected the Mouse Rab17 protein (arrow).| Product Name | Rab17 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | Rab17 Ras-related protein Rab-17 |
|---|---|
| Molecular Weight(MW) | 23640 Da |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post- endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development. May also play a role in cell migration |
| Tissue Specificity | Expressed in kidney, liver, and intestine mainly by epithelial cells. Expressed in hippocampus (at protein level) |
| Cellular Localization | Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Cell projection, dendrite. Note=According to a report the protein is localized at the basolateral and apical plasma membrane of kidney epithelial cells (PubMed:8486736). It was later shown to localize to the apical recycling endosome in epithelial cells (PubMed:21291502). In neurons, localizes to the cell body and dendritic shaft and spine |
| Entrez Gene | 19329 |
|---|---|
| Nucleotide Accession | NP_001153197.2 |
Application
Mouse Rab17 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the Mouse Rab17 antibody detected the Mouse Rab17 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
