Application
Mouse Ripk1 Antibody (Center) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Mouse Ripk1 antibody detected the Mouse Ripk1 protein (arrow).| Product Name | Ripk1 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Rinp, Rip |
|---|---|
| Alternative Names | Ripk1 Rinp Rip Receptor-interacting serine/threonine-protein kinase 1 Cell death protein RIP Receptor-interacting protein 1 Serine/threonine-protein kinase RIP |
| Molecular Weight(MW) | 74854 Da |
| Function | Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex (By similarity) |
| Tissue Specificity | Found at low levels in all tissues. |
| Cellular Localization | Cytoplasm. Cell membrane. |
| Entrez Gene | 19766 |
|---|---|
| Nucleotide Accession | NP_033094.3 |
Application
Mouse Ripk1 Antibody (Center) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Mouse Ripk1 antibody detected the Mouse Ripk1 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
