Application
Mouse Rnasel Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Mouse Rnasel antibody detected the Mouse Rnasel protein (arrow).Application
Mouse Rnasel Antibody (N-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Rnasel antibody detected the Rnasel protein (arrow).| Product Name | Rnasel Antibody (N-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Rns4 |
|---|---|
| Alternative Names | Rnasel Rns4 2-5A-dependent ribonuclease Ribonuclease 4 Ribonuclease L |
| Molecular Weight(MW) | 83275 Da |
| Function | Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. Might play a central role in the regulation of mRNA turnover (By similarity) |
| Tissue Specificity | Expressed in spleen, thymus, lung, testis, kidney, liver and heart |
| Cellular Localization | Cytoplasm. Mitochondrion. |
| Entrez Gene | 24014 |
|---|---|
| Nucleotide Accession | NP_036012.1 |
Application
Mouse Rnasel Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Mouse Rnasel antibody detected the Mouse Rnasel protein (arrow).
Application
Mouse Rnasel Antibody (N-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the Rnasel antibody detected the Rnasel protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
