Application
Mouse Shb Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the Shb antibody detected the Shb protein (arrow).| Product Name | Shb Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Alternative Names | Shb SH2 domain-containing adapter protein B |
|---|---|
| Molecular Weight(MW) | 54708 Da |
| Function | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells (By similarity) |
| Tissue Specificity | Expressed in heart, liver, brain and kidney (at protein level) |
| Cellular Localization | Cytoplasm (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity) Note=Associates with membrane lipid rafts upon TCR stimulation (By similarity) |
| Entrez Gene | 230126 |
|---|---|
| Nucleotide Accession | NP_001028478.1 |
Application
Mouse Shb Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the Shb antibody detected the Shb protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
