Application
Mouse Shc4 Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Mouse Shc4 antibody detected the Mouse Shc4 protein (arrow).| Product Name | Shc4 (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Shcd |
|---|---|
| Alternative Names | Shc4 Shcd SHC-transforming protein 4 Rai-like protein SHC-transforming protein D Src homology 2 domain-containing-transforming protein C4 |
| Molecular Weight(MW) | 68519 Da |
| Function | Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1 |
| Tissue Specificity | Expressed in both brain and skeletal muscle; widely expressed in brain namely olfactory bulb, cortex, hippocampus, striatum, thalamus, and brain stem (at protein level). Only expressed in melanomas. Weakly expressed in normal melanocytes and benign nevi. Highly expressed at the transition from radial growth phase to vertical growth phase and metastatic melanomas, when tumor cells acquire migratory competence and invasive potential |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction |
| Entrez Gene | 271849 |
|---|---|
| Nucleotide Accession | NP_950187.1 |
Application
Mouse Shc4 Antibody (C-term) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the Mouse Shc4 antibody detected the Mouse Shc4 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
