Application
Mouse Stk24 Antibody (Center) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the Stk24 antibody detected the Stk24 protein (arrow).| Product Name | Stk24 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Mst3, Stk3 |
|---|---|
| Alternative Names | Stk24 Mst3 Stk3 Serine/threonine-protein kinase 24 Mammalian STE20-like protein kinase 3 STE20-like kinase MST3 Serine/threonine-protein kinase 24 35 kDa subunit Mammalian STE20-like protein kinase 3 N-terminal Serine/threonine-protein kinase 24 12 |
| Molecular Weight(MW) | 47954 Da |
| Function | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress- induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase- independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. Regulates cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. Acts as a key regulator of axon regeneration in the optic nerve and radial nerve (By similarity) |
| Tissue Specificity | This Mouse Stk24 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 221-249 amino acids from the Central region of mouse Stk24. |
| Cellular Localization | Cytoplasm (By similarity). Nucleus (By similarity). Membrane (By similarity). Note=The truncated form (MST3/N) translocates to the nucleus. Co-localizes with STK38L in the membrane (By similarity) |
| Entrez Gene | 223255 |
|---|---|
| Nucleotide Accession | NP_663440.1 |
Application
Mouse Stk24 Antibody (Center) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the Stk24 antibody detected the Stk24 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
