Application
Mouse Taok2 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the Taok2 antibody detected the Taok2 protein (arrow).| Product Name | Taok2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | Kiaa0881 |
|---|---|
| Alternative Names | Taok2 Kiaa0881 Serine/threonine-protein kinase TAO2 Thousand and one amino acid protein 2 |
| Molecular Weight(MW) | 139297 Da |
| Function | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. May affect microtubule organization and stability. May play a role in the osmotic stress-MAPK8 pathway. Prevents MAP3K7- mediated activation of CHUK, and thus NF-kappa-B activation Isoform 2, but not isoform 1, is required for PCDH8 endocytosis Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14/p38 MAPK activation (By similarity) |
| Tissue Specificity | This Mouse Taok2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 414-443 amino acids from the Central region of Mouse Taok2. |
| Cellular Localization | Cytoplasmic vesicle membrane; Multi-pass membrane protein (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Found to be perinuclear and localized to vesicular compartment (By similarity) |
| Entrez Gene | 381921 |
|---|---|
| Nucleotide Accession | NP_001157246.1 |
Application
Mouse Taok2 Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the Taok2 antibody detected the Taok2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
