Application
MRGBP Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MRGBP antibody detected the MRGBP protein (arrow).| Product Name | MRGBP Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | C20orf20 |
|---|---|
| Alternative Names | MRGBP C20orf20 MRG-binding protein |
| Molecular Weight(MW) | 22417 Da |
| Function | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage |
| Tissue Specificity | This MRGBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-75 amino acids from the Central region of human MRGBP. |
| Cellular Localization | Nucleus. |
| Entrez Gene | 55257 |
|---|---|
| Nucleotide Accession | NP_060740.1 |
Application
MRGBP Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the MRGBP antibody detected the MRGBP protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
