Application
MRC2 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MRC2 antibody detected the MRC2 protein (arrow).| Product Name | MRC2 Antibody (Center) |
|---|---|
| Antibody Type | Primary Antibodies |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:100~500 |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Synonyms | CLEC13E, ENDO180, KIAA0709, UPARAP |
|---|---|
| Alternative Names | MRC2 CLEC13E ENDO180 KIAA0709 UPARAP C-type mannose receptor 2 C-type lectin domain family 13 member E Endocytic receptor 180 Macrophage mannose receptor 2 Urokinase-type plasminogen activator receptor-associated protein CD_antigen=CD280 Flags: |
| Molecular Weight(MW) | 166674 Da |
| Function | May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs) |
| Tissue Specificity | Ubiquitous with low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus and colon Expressed in endothelial cells, fibroblasts and macrophages Highly expressed in fetal lung and kidney |
| Cellular Localization | Membrane; Single-pass type I membrane protein |
| Entrez Gene | 9902 |
|---|---|
| Nucleotide Accession | NP_006030.2 |
Application
MRC2 Antibody (Center) western blot analysis in NCI-H460 cell line lysates (35ug/lane).This demonstrates the MRC2 antibody detected the MRC2 protein (arrow).| Application Notes | WB:1:100~500 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
